An approach to the development of the economically optimal dietary concentration of Paylean, duration of the Paylean feeding, and dietary lysine concentration for finishing hog production is presented. A simulation model describing daily growth of hogs under different Paylean and lysine concentration combinations was adapted for optimizing nutrition and marketing when feed is supplemented with Paylean. Net returns per pig space per day under four alternative payment schemes are maximized based on 10-year average price levels and production costs. Profitability of Paylean is investigated, and management strategies for swine production with Paylean are developed for two representative finishing operations.