Carbofuran (Furadan®, 5G, Padma Oil Company Ltd, Bangladesh) at different five doses i.e. 0.4, 4, 8, 12 and 16 mg/kg body, weight were administered orally to five groups of adult guinea pigs (each group consisting of 5 guinea pigs) for studying the toxic symptoms and lethality, haemato-biochemical Parameters & treatment of its toxicity in guinea pigs. The lowest dose i.e. 0.4 mg/kg dose of carbofuran Was found to be non toxic for adult guinea pigs. However, the dose of 4 mg/kg body weight of carbofuran was found to be toxic without causing any mortality. Whereas the higher three doses i.e. 8, 12 and 16 mg/kg body weight caused 40, 80 and 100% mortality respectively. The toxic symptoms Produced by carbofuran treated guineapigs were restlessness, nasal secretion, sneezing, frothy salivation, incoordination, opisthotonus, shivering, muscular fasciculation, respiratory distress, recumbencey, distended abdomen and muscular paralysis, which were characteristic of anti-ChE (Cholinesterase) poisoning. Based on mortality rate, the oral acute LD50 was calculated as 7.5mg/kg body weight in adult guinea pigs. The activities of SGPT and SGOT were increased significantly (p<0.01) to extent of 22-119% and 48-114% respectively following higher four doses of carbofuran (4, 8, 12 and 16 mg/kg b.wt.). Similarly, total leukocyte count (TLC) was increased significantly (p<0.01) upto 4-26% following higher four doses. On the other hand total erythrocyte count (TEC) and haemoglobin (Hb) content were decreased significantly upto 6-30% and 7-31% respectively following higher four doses of carbofuran (4-16 mg/kg). Packed cell volume (PCV) values were not altered following any of the five doses of carbofuran. Blood glucose level was significantly increased (p<0.01) to the extent of 9- 26% following four doses of Furadan® (4-16 mg/kg bwt.), whereas glucose level was unaffected following nontoxic dose (0.4 mg/kg b.wt.) In survivors, the altered biochemical and hematological values returned to pre-exposure level within 7-14 days of insecticide feeding. On comparing the therapeutic efficacy between atropine sulphate alone and atropine sulphate plus taste) (frusemide), it could be concluded that the combined therapy was found to be better against Furadan® poisoning in guinea pigs.