African indigenous vegetables (AIVs) hold potential to address food security and nutrition in Africa. Their production and consumption remain constrained by lack of quality seed. Efforts to promote commercial seed production lack information about the effective demand of AIV seed. This study estimated derived demand for input seed in central Uganda using trans-log production model. Own-price and cross-price elasticities for production inputs were estimated using marginal approach. Seed demand analysis showed that farmers would utilise seed from market sources of approximately 32 tons per year, against current formal supply of 4.4 tons. Estimated price elasticities showed that purchased seed was less sensitive to its own price, implying less significant effect of price change on the quantity of seed demanded over time. Seed production exhibited higher gross margins and returns to labour day compared to vegetable production, suggesting prospects of profitability and sustainability of farmer-seed enterprises as an alternative source of quality seed for farmers.