The study examines the dynamic effect of positive and negative monetary policy shocks on industrial output in Nigeria. Quarterly secondary data covering the period from 1986 to 2015 were used for the study. Applying Autoregressive Distributed Lag (ARDL), the results shows that both negative monetary policy shocks and positive monetary policy shocks have negative effect on industrial output in Nigeria both in the short run and in the long run. The study recommend that monetary policy should the used with caution in Nigeria.