Through analyzing the soil organic matters (N, P, K) of farmland cultivated with different years of Panax ginseng, this paper studied the changes in soil nutrients of farmland with different vertical depths and cultivation years of P. ginseng. Results indicated that the vertical structure was obvious in soil nutrients of farmland with different cultivation years of P. ginseng; in most cases, the soil nutrient content gradually declined with the fibrous roots of P. ginseng spreading downward; the soil electrical conductivity (EC), total nitrogen (TN), total phosphorus (TP), total potassium (TK), available nitrogen, available phosphorus were manifested as surface layer > root layer > bottom layer, while the available potassium was manifested as surface soil and bottom layer > root layer; the soil pH changed in the range of 5.69-6.22, suitable for growth of P. ginseng. It is expected to provide theoretical basis for improvement of soil nutrients of farmland with cultivation of P. ginseng.