Taking Scientific Outlook on Development as the guiding principle, this paper introduced the principles of innovation, coordination, green, openness and sharing. Based on gifted advantages of selenium-enriched soil and selenium-enriched industry development in Guangxi, it discussed current practice, stressed green, ecological, characteristic demonstration, transformation and upgrading, and targeted poverty alleviation. Finally, it came up with perspective, practical, and operational strategies and recommendations for development of selenium-enriched industry, to provide reference for sustainable development of selenium-enriched functional industry in Guangxi.