Marx’s theory of man and nature is an indispensable important constituent of Marx’s society development theory. The humanity is not always there, and they come from natural world and are long-term development products of the nature. Man has the undeniable dependence on the nature, but this kind of dependence is not the negative adaptation and is that the humanity has the huge motility to the nature. It should correctly process the relation between man and nature, and realize positive cycle and coordinated development between natural ecology and human society. It has the significant theory value and the practical significance for human society's sustainable development to grasp and comprehend scientific connotation of Marx’s theory of man and nature.