Science and technology parks have been a major driver of both the commercialization of agricultural innovation and the financial success of many farm and agribusiness firms. Therefore, the main purpose of this study was to explain the factors affecting commercialization of agricultural innovation in Kermanshah Science and Technology Park. The experts of this center were sampled by the census method (N=110). Structural equation modeling was used to analyze the data. Research findings indicated that factors affecting commercialization of agricultural innovation in Kermanshah Science and Technology Park included support of small and medium enterprise firms, relationship of parks with universities and research centers, and consequence of commercialization for agricultural sectors and research centers.