The present research carried out to study the relationship of market orientation and innovation and their effect on entrepreneurship and value creation for customers. To do so, as the sample was unlimited, 241 active companies in agriculture and food industry were selected as the samples by random sampling method. Via standard questionnaire, we gathered data on managers and senior experts' opinions about marketing and sales in each of the enterprises and analyzed data using the construct equations and with the help of SPSS and LISERL software. The results showed that market orientation affected entrepreneurship; value creation for customers, and innovation in entrepreneurship and value creation on customer have significantly affected. Also, the adjustability effect of innovation was confirmed on relationships between market orientation and entrepreneurship, and between market orientation and value creation for customers. According to the findings, it was illustrated that entrepreneurship did not have a significant effect on value creation for customers and also the innovation factor could not adjust the relationship between entrepreneurship and value creation for customers.