There were summarized main positions of constant development of Ukraine, there were discovered and described the main factors which provide it: environmental, economic and social. There were found basic directions of Renewing the management of regional social and economic sectors related to the integration and union of the efforts of government, socially responsible business and people of the region to solve the most important tasks which are related to creating a comfortable and safe environment for human life. It was studied the advantages and revealed the main aspects of functioning the cluster model of socio-economic development, which give possibility to the cluster not only to occur, but also to ensure its viability, self-sufficiency, successful and effective organization. It was considered practical examples of using of cluster model of regional development on the example of tourist and agriculture clusters. It was offered a structural model of constant regional development, which is based on cluster structure.