The paper aimd to determine the profitability of various weed control methods in potato cultivation. Mechanical cultivation and four methods of mechanical-chemical care with the use of herbicides and their mixtures have been applied to the experiment. The economic effectiveness of the five methods of weed control in potato cultivation was conditioned by costs of weeding operations, herbicide prices, the level of yield and its value. The highest profitability of weed management was found in the subjects 3. and 5., where mechanical treatment have been applied since its growth. However, before the growth, subjects had been treated by the mixture of herbicides: Command 480 EC 0.2 l/ha + Dispersive Afalon 450 SC 1.0 l/ha (subject 3.) and Stomp 400 SC 3.5 l/ha + Dispersive Afalon 450 SC 1.0 l/ha (subject 5.).