Over the past decade trade in agricultural commodities and movement of people have increased considerably, and this has resulted in a surge in worldwide movement and establishment of non-indigenous invasive species in the Greater Caribbean Basin. With further trade liberalization likely, the onslaught of invasive species will continue to increase, and the expected gains from increased product trade and movement of people will continue to be offset and undermined by damage caused by introduced alien species. Workshop participants were in agreement that a regional safeguarding strategy is essential to stemming the onslaught of invasives. Progress toward developing a Greater Caribbean Basin safeguarding system could be facilitated by the Caribbean Agricultural Health and Food Safety Agency, which is expected to come into operation in the near future, and which may enter into relevant partnerships.