Utilizing the stochastic frontier approach, this paper estimates output and input-oriented technical and scale efficiency levels for a sample of cotton-growing farms in Thessaly, Greece. The empirical results suggest that Greek cotton farm operations are technically and scale inefficient. There is a considerable scope for improvement in resource use and thereby in farm income of cotton farms; Greek cotton farmers could reduce production costs by 20.4%, making more efficient utilization of the existing production technology. Factors responsible for the technical efficiency differentials observed among cotton-growers include the farmer's age and education as well as the farm's land fragmentation and output specialization.