The objective of this paper is to evaluate the economic returns and risk associated with alternative crop residue management and tillage strategies in two different locations in Mississippi over the 2012 to 2014 crop years. It was found that in the irrigated production systems employed at Stoneville, there was no difference in the burn versus no-burn treatments. At the dryland production site in Verona, the TerraTill-bedroll system appears to be a consistently high performer for corn production. For Verona, no consistent results seem to appear for soybean production between the alternate tillage systems. At the irrigated site in Stoneville, no tillage system for either corn or soybean production seems to be consistently superior in generating net returns above tillage systems and residue management system.