This paper attempts to provide a comprehensive analysis of interrelationships among the determinants of the Quality of Life (QOL). We show that various measures of well-being are highly sensitive to domains of QOL that are considered in the construction of comparative indices, and how measurable inputs into the well-being indicators are aggregated and weighted to arrive at composite measures of QOL. We present a picture of conditions among the 43 countries of the world with respect to such interrelated domains of QOL as the relationship with family and friends, emotional well-being, health, work and productivity, material well-being, feeling part of one's community, personal safety, and the quality of environment. On the basis of Borda Rule and the principal components approach, we search for factor-indices that may function as QOL indices comparatively across countries. Such indices can be useful in making QOL comparisons and evaluations with reference to both time and place. Comparing and analyzing well-being conditions among countries in this way are aimed at facilitating the discovery of extant of problems with government policies impacting QOL.