This study evaluates profitability of crop production with variable rate technology (VRT) for P&K application relative to profitability of crop production with uniform rate technology (URT) using data from six fields with a corn-soybeans rotation situated in Indiana. The results suggest that crop production using VRT is more profitable than using URT in one of the six fields. In the case of the other five fields profitability of crop production using VRT relative to using URT falls in the range of 85 to 92%. Under the assumption of lower costs for field diagnostic services and variable rate fertilizer application profitability of crop production using VRT increases.