It is an ultimate objective to solve the rural supporting problems to improve life satisfaction of empty nesters in rural areas. Based on data of 546 empty nesters in rural areas, the factors influencing life quality satisfaction of empty nesters in rural areas are firstly analyzed using ordered logit model, and then the relationship between various influencing factors is analyzed using ISM. Study shows that health condition, degree of participation in cultural and sports activities, spouse status, family harmony degree, annual family income, degree of worry about life, degree of government and social care and pension mode, have a significant impact on the life quality satisfaction of empty nesters in rural areas. The degree of worry about life, degree of government and social care are surface direct factors; degree of participation in cultural and sports activities, family harmony degree, pension mode are intermediate indirect factors; health condition, spouse status and annual family income are deep root factors.