This paper made scientific analysis on asynchronous MES for discipline of College Japanese in characteristic campus of agriculture-related universities. It made modular design for discipline of College Japanese in emotional concept, language skill, language knowledge, learning strategy, and cultural quality combining students’ demands and education and teaching rules. Relying on Internet and Mobile Internet aided teaching platform, it came up with “Integration – Separation – Integration” asynchronous teaching approach. The practice indicates that teaching effect of such approach is remarkable. However, asynchronous MES for discipline of College Japanese raises higher requirement for interaction between teachers and students and voluntary effort of teachers.