This paper analyzes the cost efficiency impacts of adopting biotechnology-enhanced soybean varieties for a set of Kansas farms from 1993 to 2011 using cost indices estimated from linear programming techniques. The cost efficiency indices are then coupled with survey data about the adoption of biotechnology-enhanced soybean varieties to provide a comparative analysis over time and across different quartiles of the sample. Results indicate that cost efficiency is not likely to decline on average with the adoption of these soybean varieties, but may increase for more efficient farms through a number of different benefits associated with adoption.