Under the background of economic globalization, the development mechanisms of various regions faces potential deep transformation, and the effective participation of less developed areas in China in economic globalization is of great significance to the sustainable development of Chinese economy and society. In this study, we summarized the characteristics and influences of economic globalization from the aspects of industrial recombination and transfer, competition, economic relevance and development modes, and analysed the opportunities and challenges of land use in less developed areas brought by economic globalization. Afterwards, based on the major problems of land use plan management in the middle of Jiangsu Province, we put forward many suggestions like management of planning process, balanced development of ecology and economy, strengthening plan use zoning, spatial agglomeration and protecting cultural diversity to response to economic globalization.