This paper evaluates Indiana’s economy by using an input-output (I-O) model to decompose output growth of two sectors into regional demand, external demand, the progress of import substitutions, and technological change. We use the Syrquin (1976, 1986, 1988) industry decomposition method to perform this analysis. We examine two industries that have been central to state level economic development policy: logistics and manufacturing of life sciences products. We found that the logistics sector has responded slowly during the post-recession growth experienced by many of the remaining sectors. However, the surgical sector performed well in terms of deepening interindustry linkages.