Epizootic outbreaks such as Foot and Mouth Disease are of great concern for agriculture. In this paper, we quantify the potential dynamic impacts of such a disease on Brittany, a French region with a strong livestock sector. We develop a dynamic computable general equilibrium model with rational expectations that allows us to measure the impacts of culling infected animals and restraining movements of live animals on the livestock sectors and downstream food industries. Our results show that economic losses are spread over many periods even with a one-time shock. The impacts on the primary sectors and downstream food sectors do not move in parallel. The food industries suffer most in the first period while the negative impacts on agriculture are mostly observed thereafter. Credit and wage constraints result in an estimated aggregated loss multiplied by more than 700 per cent. These results challenge the concept of a simple management policy for this disease.