A deterministic model for the economic impact of African Horse Sickness (AHS) on the equine breeding industry was developed for South Africa. It was applied to the case of the 2007/2008 outbreak of AHS in the Eastern Cape as a pilot application of the model, using data from breeders in the province. It was concluded that the deterministic model’s extension to include other areas of equine livelihoods could be effective in exposing the need for further research into the control and treatment of AHS in South Africa.