The process of acquiring an infection has two components: first, exposure through proximity to another infected individual, and second, transmission of the disease. Earlier studies of the socioeconomic factors that affect the probability of acquiring an illness assume uniform exposure to infected individuals and may therefore result in biased estimates. This paper develops an empirical model, consistent with epidemiological models of spread of infections, to estimate the impact of socioeconomic variables on the extent of disease transmission within villages in Cambodia. Data from the 1997 Cambodia Socioeconomic Survey are used in this analysis.