Contagious animal diseases like foot-and-mouth disease (FMD) are often referred to as economic diseases because of the magnitude of economic harm they can cause to producers and to local communities. This study demonstrates the local economic impact of a hypothetical FMD outbreak in southwest Kansas, an area with high density of cattle feeding. The expected (most probable) economic impact of the disease hinges heavily on where the incidence of the disease occurs. If the disease were to occur in a cow-calf herd in the region economic impact is expected to be relatively small compared to if it were introduced simultaneously in five large feedlots in southwest Kansas. Disease surveillance, management strategies, mitigation investment, and overall diligence clearly need to be much greater in concentrated cattle feeding and processing areas at the large feeding operations in the region.