This paper constructs the index system and econometric model of comprehensive evaluation on urban competitiveness, then adopts the factor analysis method to measure the urban competitiveness of 22 prefecture-level cities in Xinjiang Province. The 22 prefecture-level cities are divided into four levels according to the measurement result. Comprehensive analysis of the advantages and disadvantages of the cities in each level is carried out. And related countermeasures and proposals on how to improve the urban competitiveness of the 22 cities are put forward.