The Energy Policy Act of 2005 includes a provision designed to double the production and use of ethanol in fuels by 2012, and that beginning in 2013, a minimum of 250 million gallons per year of ethanol be produced from lignocellulosic sources such as corn stover, wheat straw, and switchgrass. This study was conducted to determine the environmental and health consequences of using ethanol as an additive to gasoline. Comparisons are made among conventional gasoline (CG), a blend of 10 percent corn-ethanol and 90 percent CG (E10-corn), and a blend of 10 percent ethanol produced from lignocellulosic biomass (LCB) and 90 CG (E10-LCB).