Land is rare natural resource. Production and construction of all sectors in a region must be based on land. Thus, overall research and analysis on current situation of land use can reveal scope, depth and reasonableness of land use, is helpful for analyzing internal mechanism land use change, and can reflect production scale, level and characteristics, and also can provide basis for optimization and adjustment of land use structure. Based on RS and GIS technologies, with the aid of TM image data of the Three-Gorges Reservoir Region in 2010, the data of current situation of land use in Three-Gorges Reservoir Region was obtained, and current land use situation was analyzed using geographimetrics and landscape ecology methods. Results show that since natural, social and economic conditions are different, land type diversity, combination type and location index of counties in the Three-Gorges Reservoir Region are varied. In the land use diversity index, Xingshan County has the most single land use type (mainly forest land); in land use degree, Yuzhong District has the highest land use degree; in the integrated index of land use, Changshou District has the lowest integrated index of land use. This study is expected to provide reference and basis for formulating policies of protecting ecological environment of the Three-Gorges Reservoir Region.