Firstly, based on significance of developing agricultural mechanization and automation and current situations of agricultural mechanization and automation specialities in colleges and universities, we put forward objectives of personnel cultivation for agricultural mechanization and automation specialities. Then, we analyze the exploration and practice of personnel cultivation for agricultural mechanization and automation specialities from four aspects, including course system setting, teaching materials construction, laboratory construction, and construction of practical teaching link. Finally, it is expected to provide references for running schools and cultivating excellent professional personnel.